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Maud Leonora Menten (March 20, 1879 – July 26, 1960) was a Canadian physician-scientist who made significant contributions to enzyme kinetics and histochemistry. Her name is associated with the famous Michaelis–Menten equation in biochemistry. Maud Menten was born in Port Lambton, Ontario and studied medicine at the University of Toronto (B.A. 1904, M.B. 1907, M.D. 1911). She was among the first women in Canada to earn a medical doctorate.〔 She completed her thesis work at University of Chicago. At that time women were not allowed to do research in Canada, so she decided to do research in other countries such as the United States and Germany. In 1912 she moved to Berlin where she worked with Leonor Michaelis and co-authored their paper in ''Biochemische Zeitschrift''〔 which showed that the rate of an enzyme-catalyzed reaction is proportional to the amount of the enzyme-substrate complex. This relationship between reaction rate and enzyme-substrate concentration is known as the Michaelis-Menten equation. After studying with Michaelis in Germany she entered graduate school at the University of Chicago where she obtained her PhD in 1916. Her dissertation was titled "The Alkalinity of the Blood in Malignancy and Other Pathological Conditions; Together with Observations on the Relation of the Alkalinity of the Blood to Barometric Pressure". Menten worked at the University of Pittsburgh (1923–1950), becoming an assistant and then associate Professor in the School of Medicine and head of pathology at the Children's Hospital of Pittsburgh. Her final promotion to full Professor, in 1948, was at the age of 70 in the last years of her career.〔 Her final academic post was as a research fellow at the British Columbia Medical Research Institute (1951–1953). ==Early life== Little is known about her parents and childhood other than that the Menten family moved to Harrison Mills, where Maud's mother worked as a postmistress. After completing secondary school, Menten attended the University of Toronto where she earned a bachelor of arts degree in 1904 and a master's degree in physiology in 1907. While earning her graduate degree, she worked as a demonstrator in the university's physiology lab. A talented student, Menten was appointed a fellow at the Rockefeller Institute for Medical Research in New York City in 1907. There, she studied the effect of radium bromide on cancerous tumors in rats.〔 Menten and two other scientists published the results of their experiment, producing the institute's first monograph.〔 After a year at the Institute, Menten worked as an intern at the New York Infirmary for Women and Children. She returned to Canada and began studies at the University of Toronto a year later. In 1911 she became one of the first Canadian women to receive a doctor of medicine degree.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Maud Menten」の詳細全文を読む スポンサード リンク
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